Palmerston–Little Italy is a neighbourhood in central Toronto, Ontario, Canada. Its boundaries, according to the City of Toronto, are by Bathurst Street to the east, Bloor Street to the north, Dovercourt Road to the west and College Street to the south. It is a mature downtown neighbourhood. Within this official neighbourhood of the City of Toronto are two neighbourhoods, Palmerston and Little Italy and the commercial enclave of Mirvish Village.
The neighbourhood is primarily residential, consisting mainly of residential side streets full of semi-detached homes, mostly built in the early 20th century. The major streets are Bloor Street to the north, running east-west, a four-lane arterial road commercial in nature. Bloor Street has many commercial storefronts and businesses. To the east is Bathurst Street, running north-south, another four-lane arterial road with mostly residences along both sides. Running east-west is Harbord Street, a four-lane arterial road with a mix of residences and commercial storefronts and restaurants. Also running east-west is College Street a four-lane arterial road with a vibrant commercial strip named Little Italy, one of the original ethnically-Italian districts of Toronto. To the west, north-south streets include Ossington Avenue, a four-lane arterial road, mainly residential and Dovercourt Road, a four-lane road, entirely residential. In the north-east corner of the neighbourhood is “Mirvish Village”, a one-block long enclave of businesses, mostly of arts, immediately west and extending south of the “Honest Ed’s” discount department store at Bathurst and Bloor.